Long-established Belper firm Deb Ltd is moving from the town after more than 60 years.
Deb Ltd, in Spencer Road, will re-locate to a new 20 million purpose-built site in Denby in an ambitious move to expand the industrial cleaning firm.
The new site, on Derby Road, near Denby Pottery, is set to be up and running by the end of 2009. The 180-strong staff from the Belper factory will move there in stages.
Deborah Freeman, spokeswoman for the company, said Deb had outgrown its current premises.
She said: "The current situation is that the Belper factory is an obstacle to future growth of the company. The site is no longer fit for its purpose."
The company, best known for producing hand cleaner Swarfega, also has
offices in Burton and warehouses at Junction 28 of the M1, at Kirkby in Ashfield.
The Denby site will accommodate all 225 staff from the three sites, making the production process more streamlined.
Ms Freeman said: "All the staff are really excited about the new facilities they will have."
She said there would be no redundancies as a result of the relocation and no-one would be out of work for any period of time.
Executives at Deb chose Denby because of its convenient links with the motorway and it was the least disruptive option for transferring staff.
John Nelson, leader of Belper Town Council, welcomed the move and did
not think it would affect the town badly.
He said: "I think it's wonderful that Deb is moving. It seems clear that Belper is not built for big industries. I've seen lorries blocking roads at night and obstructing pavements because there isn't enough room for them.
"It's been a problem round that area for some time. It's only moving a very short distance so it will not affect the workforce and it can only be a benefit to the town."
Chairman of Denby Parish Council, Mick Clare, said: "I think its good that the jobs are being retained in Amber Valley and we welcome the firm to the area.
"We obviously have some reservations regarding vehicle movement as there is a lot of development going on at Denby Hall. But we are talking to Amber Valley Borough Council regarding the impact it will have on the area."
The company has been in Belper since 1941. It now produces 20 industrial cleaning products and supplies more than 100 countries.
It was established by A.B Williamson, of Heanor, as Deb Silk, before he invented Swarfega in 1947.