An estimated 10 tonnes of rubbish is to be cleared from the A38 dual carriageway in Amber Valley.
Rubbish will be collected from over 30 miles of verges across 10 miles of road network as part of the £6,000 clear up operation commissioned by Amber Valley Borough Council, in partnership with Highways Agency contractors, Aone+.
By doing the clear up in partnership with Aone+ the Council said it would save up on expensive lane closures, which cost up to £22,000 each year.
Work is due to start on Tuesday, August 27 and will last for up to two weeks.
Specially trained staff will also be carrying out grass cutting from Coxbench to Alfreton.
A traffic management system will be used to slow traffic close to the areas being cleared.
The work will be done overnight between 8pm and 6am.
Councillor Liz Bowley, Cabinet Member for Green and Thriving Places to Live said: “Our innovative partnership with the Highways Agency has saved tens of thousands of pounds.
“Of course, that cost would be further reduced if inconsiderate motorists kept their litter in their vehicles instead of using the hard shoulder as a litter bin!”
Waste tyres, car parts, bottles, cardboard boxes and used nappies are among the items which are recovered from the roadside each year.
Thousands of cigarette ends are also discarded but are more difficult and expensive to clear because of their size.
People can be fined up to £80 on the spot for dropping litter.